Every episode starts with a different introduction slogan. This is something Matt Groening also does with The Simpsons, where Bart writes something different on the blackboard every time.

The Simpsons also has a different couch gag every episode. Futurama’s introduction always ends with the Planet Express Ship flying into a large screen showing a vintage cartoon. This time it actually flies into the screen and we get to see what Futurama would have looked like a century ago.

Fry’s new polygamous girlfriend Colleen is voiced by Brittany Murphy.

All My Circuits’ Calculon also makes an appearance or two in The Beast With A Billion Backs. It turns out, his fourth different personality is blackmailing himself…